SCHEMBL29929626

SCHEMBL29929626

CCOc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)ccc1O

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 3/20 0.89
AKR1B1 P15121 3/20 0.76
MAOB P27338 3/20 0.76
ABCB1 P08183 2/20 0.76
MAOA P21397 2/20 0.76
BACE1 P56817 7/20 0.66
APP P05067 6/20 0.66
MAPT P10636 6/20 0.66
CYP2D6 P10635 2/20 0.66
CYP2C9 P11712 2/20 0.66
TSHR P16473 2/20 0.66
HSD17B10 Q99714 2/20 0.66
HDAC3 O15379 2/20 0.66
HDAC1 Q13547 2/20 0.66
HDAC2 Q92769 2/20 0.66
HDAC6 Q9UBN7 2/20 0.66
PTGS2 P35354 2/20 0.66
GLO1 Q04760 2/20 0.66
CAMK2A Q9UQM7 2/20 0.66
ALDH1A1 P00352 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethyl Curcumin SCHEMBL8965258 0.94 TOP2A (1.00) TOP2AAKR1B1MAOBABCB1MAOA
Ethyl Curcumin SCHEMBL8965263 0.94 TOP2A (1.00) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL1374497 0.89 TOP2A (0.89) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL27686673 0.89 TOP2A (0.89) TOP2AAKR1B1MAOBABCB1MAOA
Water SCHEMBL28118110 0.88 TOP2A (0.87) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL2622443 0.88 TOP2A (0.87) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL27211484 0.87 TOP2A (0.86) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL2553051 0.86 ABCB1 (1.00) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL13521973 0.86 ABCB1 (1.00) TOP2AAKR1B1MAOBABCB1MAOA
SCHEMBL431246 0.86 ABCB1 (1.00) TOP2AAKR1B1MAOBABCB1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO disclosed