Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.86 |
| ▸ | IAPP | P10997 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | APP | P05067 | 4/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.62 |
| ▸ | MAOB | P27338 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | BACE1 | P56817 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 2/20 | 0.62 |
| ▸ | ALPI | P09923 | 2/20 | 0.62 |
| ▸ | ALPG | P10696 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Curcumin SCHEMBL8965258 | 0.93 | TOP2A (1.00) | TOP2AALDH1A1APPABCB1MAOB | |
| Ethyl Curcumin SCHEMBL8965263 | 0.93 | TOP2A (1.00) | TOP2AALDH1A1APPABCB1MAOB | |
| SCHEMBL14157952 | 0.89 | TOP2A (0.68) | TOP2AIAPPALDH1A1APPABCB1 | |
| SCHEMBL1374497 | 0.87 | TOP2A (0.89) | TOP2AALDH1A1APPABCB1MAOB | |
| SCHEMBL27686673 | 0.87 | TOP2A (0.89) | TOP2AALDH1A1APPABCB1MAOB | |
| SCHEMBL29929626 | 0.87 | TOP2A (0.89) | TOP2AALDH1A1APPABCB1MAOB | |
| SCHEMBL3859807 | 0.87 | APP (0.83) | TOP2AIAPPALDH1A1APPABCB1 | |
| SCHEMBL3859809 | 0.87 | APP (0.83) | TOP2AIAPPALDH1A1APPABCB1 | |
| SCHEMBL4621488 | 0.87 | TOP2A (0.78) | TOP2AALDH1A1APPABCB1MAOB | |
| SCHEMBL31380860 | 0.87 | TOP2A (0.78) | TOP2AALDH1A1APPABCB1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250011293-A1 | LEUKOTRIENE SYNTHESIS INHIBITORS | NAEGIS PHARMACEUTICALS INC. (CA) | 2025-01-09 | — | — | US | disclosed |
| US-11976052-B2 | Leukotriene synthesis inhibitors | NAEGIS PHARMACEUTICALS INC. (CA) | 2024-05-07 | — | — | US | disclosed |
| US-20220064132-A1 | LEUKOTRIENE SYNTHESIS INHIBITORS | NAEGIS PHARMACEUTICALS INC. (CA) | 2022-03-03 | — | — | US | disclosed |
| CN-113784713-A | Leukotriene synthesis inhibitors | 纳吉斯制药股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064132-A1 | LEUKOTRIENE SYNTHESIS INHIBITORS | LTC4S, LTB4R2, LTA4H | TOP2A 4511/4885IAPP 2392/4885ALDH1A1 2274/4885 |
| US-11976052-B2 | Leukotriene synthesis inhibitors | LTC4S, LTB4R2, LTA4H | TOP2A 4511/4885IAPP 2392/4885ALDH1A1 2274/4885 |
| US-20250011293-A1 | LEUKOTRIENE SYNTHESIS INHIBITORS | LTC4S, LTB4R2, LTA4H | TOP2A 4511/4885IAPP 2392/4885ALDH1A1 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.