Patuletin

Patuletin

SCHEMBL29929679

COc1c(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 3/20 0.86
AMY1A P0DUB6 3/20 0.71
PIM1 P11309 2/20 0.71
CD38 P28907 2/20 0.71
TUBB4A P04350 4/20 0.70
TUBB P07437 4/20 0.70
TUBA3C P0DPH7 4/20 0.70
TUBA1B P68363 4/20 0.70
TUBA4A P68366 4/20 0.70
TUBB4B P68371 4/20 0.70
TUBB3 Q13509 4/20 0.70
TUBB2A Q13885 4/20 0.70
TUBB8 Q3ZCM7 4/20 0.70
TUBA3E Q6PEY2 4/20 0.70
TUBA1A Q71U36 4/20 0.70
TUBA1C Q9BQE3 4/20 0.70
TUBB6 Q9BUF5 4/20 0.70
TUBB2B Q9BVA1 4/20 0.70
TUBB1 Q9H4B7 4/20 0.70
NR0B1 P51843 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Patuletin SCHEMBL1144553 1.00 XDH (0.86) XDHAMY1APIM1CD38TUBB4A
Patuletin SCHEMBL29929193 1.00 XDH (0.86) XDHAMY1APIM1CD38TUBB4A
Axillarin SCHEMBL29929599 0.92 XDH (1.00) XDHAMY1ATUBB4ATUBBTUBA3C
Axillarin SCHEMBL1155670 0.92 XDH (1.00) XDHAMY1ATUBB4ATUBBTUBA3C
Axillarin SCHEMBL29929648 0.92 XDH (1.00) XDHAMY1ATUBB4ATUBBTUBA3C
SCHEMBL19461012 0.90 TUBB4A (0.74) XDHTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL29647956 0.90 TUBB4A (0.74) XDHTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL31058466 0.90 MKNK2 (0.86) XDHMKNK2NOX4ALOX5ABCB1
SCHEMBL29143220 0.90 MKNK2 (0.86) XDHMKNK2NOX4ALOX5ABCB1
SCHEMBL31675806 0.88 TUBB4A (0.71) XDHPIM1TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO disclosed