Axillarin

Axillarin

SCHEMBL29929599

COc1c(O)cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 1.00
TUBB4A P04350 5/20 0.82
TUBB P07437 5/20 0.82
TUBA3C P0DPH7 5/20 0.82
TUBA1B P68363 5/20 0.82
TUBA4A P68366 5/20 0.82
TUBB4B P68371 5/20 0.82
TUBB3 Q13509 5/20 0.82
TUBB2A Q13885 5/20 0.82
TUBB8 Q3ZCM7 5/20 0.82
TUBA3E Q6PEY2 5/20 0.82
TUBA1A Q71U36 5/20 0.82
TUBA1C Q9BQE3 5/20 0.82
TUBB6 Q9BUF5 5/20 0.82
TUBB2B Q9BVA1 5/20 0.82
TUBB1 Q9H4B7 5/20 0.82
NR0B1 P51843 1/20 0.82
MAPT P10636 4/20 0.77
PKM P14618 1/20 0.77
MEN1 O00255 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Axillarin SCHEMBL29929648 1.00 XDH (1.00) XDHTUBB4ATUBBTUBA3CTUBA1B
Axillarin SCHEMBL1155670 1.00 XDH (1.00) XDHTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13697259 0.94 XDH (0.88) XDHTUBB4ATUBBTUBA3CTUBA1B
Patuletin SCHEMBL29929193 0.92 XDH (0.86) XDHTUBB4ATUBBTUBA3CTUBA1B
Patuletin SCHEMBL1144553 0.92 XDH (0.86) XDHTUBB4ATUBBTUBA3CTUBA1B
Patuletin SCHEMBL29929679 0.92 XDH (0.86) XDHTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13560795 0.90 TUBB4A (0.86) XDHTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL29649084 0.90 TUBB4A (0.86) XDHTUBB4ATUBBTUBA3CTUBA1B
Centaureidin SCHEMBL9953 0.90 TUBB4A (1.00) XDHTUBB4ATUBBTUBA3CTUBA1B
Chrysosplenol D SCHEMBL29359614 0.90 ALOX5 (0.83) XDHTUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
US-20250111889-A1 DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES UNIVERSITY OF WASHINGTON 2025-04-03 US disclosed
CN-118647375-A Composition derived from sorghum for food coloring and antioxidant supplementation 红叶生物制品有限公司 2024-09-13 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250111889-A1 DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES DHFR, CCNH, ODC1 XDH 2161/4885TUBB4A 1237/4885TUBB 442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.