Sugi Predict

Sugi Predict / Compounds / SCHEMBL29929920

SCHEMBL29929920

SCHEMBL29929920

COC(=O)[C@@H]1C[C@H](N(Cc2ccc(OC)cc2)C(=O)OCC(Cl)(Cl)Cl)CN1C(=O)OC(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX3 P56373 2/20 0.40
▸ CYP3A4 P08684 1/20 0.38
▸ CETP P11597 2/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ HSD11B1 P28845 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ PTPN1 P18031 1/20 0.35
▸ HTR2A P28223 4/20 0.35
▸ LMNA P02545 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ MMP1 P03956 1/20 0.35
▸ MMP3 P08254 1/20 0.35
▸ MMP7 P09237 1/20 0.35
▸ MMP9 P14780 1/20 0.35
▸ UBE2M P61081 1/20 0.35
▸ DCUN1D1 Q96GG9 1/20 0.35
▸ GPR119 Q8TDV5 1/20 0.34
▸ HDAC8 Q9BY41 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20475113 0.92 HSD11B1 (0.38) CETPMEN1KMT2AHSD11B1ALDH1A1
SCHEMBL2817569 0.91 HSD11B1 (0.43) P2RX3CETPHSD11B1PTPN1
SCHEMBL13841900 0.91 HSD11B1 (0.43) P2RX3CETPHSD11B1PTPN1
SCHEMBL20475134 0.86 HDAC8 (0.44) CYP3A4MEN1KMT2AHSD11B1ALDH1A1
SCHEMBL28345071 0.85 MEN1 (0.39) CYP3A4CETPMEN1KMT2AHSD11B1
SCHEMBL13841899 0.83 HSD11B1 (0.45) CETPHSD11B1
SCHEMBL2820222 0.83 HSD11B1 (0.45) CETPHSD11B1
SCHEMBL28345178 0.82 CHRM1 (0.39) ALDH1A1HTR2ASMN1; SMN2MMP1MMP3
SCHEMBL2818340 0.81 HTR2A (0.44) HTR2A
SCHEMBL12479425 0.79 NR1H2 (0.34) P2RX3CYP3A4CETPHSD11B1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12390446-B2 Proline-based neuropeptide FF receptor modulators RESEARCH TRIANGLE INSTITUTE (US) 2025-08-19 — — US disclosed
US-20240058303-A1 PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS RES TRIANGLE INST (US) 2024-02-22 — — US disclosed
US-11826350-B2 Proline-based neuropeptide FF receptor modulators RESEARCH TRIANGLE INSTITUTE (US) 2023-11-28 — — US disclosed
US-20230091922-A1 PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS RES TRIANGLE INST (US) 2023-03-23 — — US disclosed
US-11491136-B2 Proline-based neuropeptide FF receptor modulators RESEARCH TRIANGLE INSTITUTE (US) 2022-11-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11491136-B2 Proline-based neuropeptide FF receptor modulators NPFFR1, NPFFR2, NPBWR1 P2RX3 310/4885CYP3A4 4401/4885CETP 2827/4885
US-12390446-B2 Proline-based neuropeptide FF receptor modulators NPFFR1, NPFFR2, NPBWR1 P2RX3 310/4885CYP3A4 4401/4885CETP 2827/4885
US-11826350-B2 Proline-based neuropeptide FF receptor modulators NPFFR1, NPFFR2, NPBWR1 P2RX3 310/4885CYP3A4 4401/4885CETP 2827/4885
US-20240058303-A1 PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS NPFFR1, NPFFR2, NPBWR1 P2RX3 310/4885CYP3A4 4401/4885CETP 2827/4885
US-20230091922-A1 PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS NPFFR1, NPFFR2, NPBWR1 P2RX3 310/4885CYP3A4 4401/4885CETP 2827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.