Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 13/20 | 0.62 |
| ▸ | F13A1 | P00488 | 11/20 | 0.62 |
| ▸ | TGM1 | P22735 | 8/20 | 0.62 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22405315 | 1.00 | TGM2 (0.62) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL22406004 | 0.88 | F13A1 (0.46) | TGM2F13A1TGM1TGM3MAPT | |
| SCHEMBL22405362 | 0.86 | MEN1 (0.48) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL29004186 | 0.84 | MEN1 (0.46) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL26096244 | 0.84 | MEN1 (0.46) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL24896968 | 0.82 | MEN1 (0.44) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL22405887 | 0.82 | TGM2 (0.53) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL29930054 | 0.82 | TGM2 (0.53) | TGM2F13A1TGM1TGM3MEN1 | |
| SCHEMBL24896757 | 0.80 | NPC1 (0.44) | MEN1KMT2AMAPTTSHRSMN1; SMN2 | |
| SCHEMBL24896483 | 0.80 | KDM4E (0.48) | MEN1KMT2AMAPTLMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390604-B2 | Imidazole-pyrazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390604-B2 | Imidazole-pyrazole derivatives | F12, CYP3A7, NLRP3 | TGM2 4481/4885F13A1 1398/4885TGM1 1779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.