Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 10/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxymethane SCHEMBL2993041 | 0.86 | PDE4A (0.42) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| Methoxymethane SCHEMBL15015511 | 0.86 | PDE4A (0.42) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16865878 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6423584 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7099805 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16865875 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11982806 | 0.77 | ALDH1A1 (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11982739 | 0.77 | ALDH1A1 (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24437403 | 0.76 | ALDH1A1 (0.46) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2999171 | 0.76 | TP53 (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-B1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2014-06-04 | — | — | EP | disclosed |
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | disclosed |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-07-15 | — | — | US | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, NOS1 | ALDH1A1 1039/4885PDE4A 2306/4885PDE4B 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.