Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611728 | 1.00 | ALOX15 (0.43) | ALOX15HSD17B10LMNAMAPTKDM4E | |
| SCHEMBL23611715 | 0.91 | LMNA (0.44) | LMNAMAPTKDM4ENPSR1MAPK8 | |
| SCHEMBL29930983 | 0.91 | LMNA (0.44) | LMNAMAPTKDM4ENPSR1MAPK8 | |
| SCHEMBL29930729 | 0.89 | ALOX15 (0.47) | ALOX15HSD17B10MAPTPOLBHPGD | |
| SCHEMBL23611755 | 0.89 | ALOX15 (0.47) | ALOX15HSD17B10MAPTPOLBHPGD | |
| SCHEMBL23623493 | 0.88 | ALOX15 (0.44) | ALOX15HSD17B10LMNAMAPTKDM4E | |
| SCHEMBL23611788 | 0.84 | ALOX15 (0.43) | ALOX15HSD17B10MAPTPOLBHPGD | |
| SCHEMBL23623309 | 0.84 | ALOX15 (0.43) | ALOX15HSD17B10LMNAMAPTPOLB | |
| SCHEMBL23611738 | 0.83 | ALOX15 (0.44) | ALOX15HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL23758245 | 0.82 | MAPT (0.43) | ALOX15HSD17B10LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |