Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611715 | 1.00 | LMNA (0.44) | LMNAMAPK8HPGDMAPTKMT2A | |
| SCHEMBL29930564 | 0.91 | ALOX15 (0.43) | LMNAMAPK8HPGDMAPTKDM4E | |
| SCHEMBL23611728 | 0.91 | ALOX15 (0.43) | LMNAMAPK8HPGDMAPTKDM4E | |
| SCHEMBL23623492 | 0.89 | LMNA (0.45) | LMNAMAPK8HPGDMAPTKMT2A | |
| SCHEMBL23623267 | 0.89 | TP53 (0.42) | LMNAHPGDMAPTNPSR1TP53 | |
| SCHEMBL23611767 | 0.87 | TP53 (0.42) | LMNAHPGDMAPTTP53THRB | |
| SCHEMBL23611766 | 0.86 | CTSA (0.38) | LMNAHPGDMAPTTP53THRB | |
| SCHEMBL23623494 | 0.84 | NAMPT (0.41) | LMNAMAPTTP53THRBKCNH2 | |
| SCHEMBL23611738 | 0.84 | ALOX15 (0.44) | LMNAMAPTNPSR1TP53THRB | |
| SCHEMBL23611711 | 0.81 | ADORA3 (0.41) | LMNAHPGDMAPTTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |