Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.60 |
| ▸ | CLK1 | P49759 | 2/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | USP7 | Q93009 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930484 | 0.94 | DYRK1B (0.56) | DYRK1ADYRK1BCLK1DYRK2GSK3B | |
| SCHEMBL29930893 | 0.91 | GSK3B (0.58) | DYRK1ADYRK1BGSK3BGSK3AAXL | |
| SCHEMBL12343726 | 0.87 | DYRK1A (0.57) | DYRK1ADYRK1BGSK3BGSK3AFGFR1 | |
| SCHEMBL29930310 | 0.84 | DYRK1A (0.61) | DYRK1ADYRK1BCLK1DYRK2GSK3B | |
| SCHEMBL29930303 | 0.81 | DYRK1A (0.59) | DYRK1ADYRK1BGSK3BGSK3A | |
| SCHEMBL29930317 | 0.80 | DYRK1B (0.68) | DYRK1ADYRK1BCLK1DYRK2GSK3B | |
| SCHEMBL29930308 | 0.80 | DYRK1B (0.68) | DYRK1ADYRK1BCLK1DYRK2FGFR1 | |
| SCHEMBL12343727 | 0.79 | PIM1 (0.58) | DYRK1ADYRK1BGSK3BGSK3AFGFR1 | |
| SCHEMBL12343735 | 0.79 | CDK2 (0.67) | DYRK1AGSK3BFGFR1 | |
| SCHEMBL29930661 | 0.79 | DYRK1B (0.69) | DYRK1ADYRK1BCLK1DYRK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |