Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.56 |
| ▸ | CLK1 | P49759 | 5/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930698 | 0.94 | DYRK1A (0.60) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930310 | 0.90 | DYRK1A (0.61) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930317 | 0.85 | DYRK1B (0.68) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930308 | 0.85 | DYRK1B (0.68) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930661 | 0.84 | DYRK1B (0.69) | DYRK1BDYRK1ACLK1DYRK2CDK2 | |
| SCHEMBL29930770 | 0.84 | DYRK1B (0.58) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930893 | 0.83 | GSK3B (0.58) | DYRK1BDYRK1ACDK2GSK3BCDK5 | |
| SCHEMBL12343726 | 0.80 | DYRK1A (0.57) | DYRK1BDYRK1AFGFR1FGFR3PDPK1 | |
| SCHEMBL29930303 | 0.80 | DYRK1A (0.59) | DYRK1BDYRK1ACCNA2CDK2GSK3B | |
| SCHEMBL9877148 | 0.75 | PDPK1 (0.49) | FGFR1FGFR2FGFR3PDPK1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |