Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.67 |
| ▸ | CLK1 | P49759 | 6/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.67 |
| ▸ | PEPD | P12955 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930317 | 0.88 | DYRK1B (0.68) | DYRK1BDYRK1ACLK1DYRK2CCNT1 | |
| SCHEMBL29930773 | 0.86 | DYRK1B (0.70) | DYRK1BDYRK1ACLK1DYRK2CCNT1 | |
| SCHEMBL29930484 | 0.85 | DYRK1B (0.56) | DYRK1BDYRK1ACLK1DYRK2CCNT1 | |
| SCHEMBL29930698 | 0.80 | DYRK1A (0.60) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930661 | 0.80 | DYRK1B (0.69) | DYRK1BDYRK1ACLK1DYRK2CDK2 | |
| SCHEMBL29930310 | 0.77 | DYRK1A (0.61) | DYRK1BDYRK1ACLK1DYRK2FGFR1 | |
| SCHEMBL29930667 | 0.75 | DYRK1B (0.70) | DYRK1BDYRK1ACLK1DYRK2CDK2 | |
| SCHEMBL29930770 | 0.72 | DYRK1B (0.58) | DYRK1BDYRK1ACLK1DYRK2CDK9 | |
| SCHEMBL29930893 | 0.71 | GSK3B (0.58) | DYRK1BDYRK1ACDK2 | |
| SCHEMBL1322717 | 0.70 | PEPD (1.00) | PEPDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |