Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.58 |
| ▸ | GSK3A | P49840 | 4/20 | 0.58 |
| ▸ | CDK8 | P49336 | 5/20 | 0.54 |
| ▸ | AXL | P30530 | 3/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | FER | P16591 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930698 | 0.91 | DYRK1A (0.60) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL12343727 | 0.88 | PIM1 (0.58) | GSK3BGSK3ACDK8AXLPIM1 | |
| SCHEMBL12343726 | 0.86 | DYRK1A (0.57) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL5537040 | 0.85 | GSK3B (0.49) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL5387619 | 0.84 | GSK3B (0.59) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL5534996 | 0.84 | GSK3B (0.48) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL5061384 | 0.83 | DYRK1A (0.57) | GSK3BGSK3ACDK8PIM1PLK4 | |
| SCHEMBL29930484 | 0.83 | DYRK1B (0.56) | GSK3BCDK2CDK5CLK4MAP2K4 | |
| SCHEMBL7168419 | 0.83 | GSK3B (0.56) | GSK3BGSK3ACDK8AXLTNIK | |
| SCHEMBL1592857 | 0.83 | ALDH1A1 (0.46) | GSK3BGSK3AAXLPIM1PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |