Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930701 | 0.82 | DYRK1B (0.67) | DYRK1ADYRK1BRAB9AMAPTACP1 | |
| SCHEMBL29930670 | 0.78 | DYRK1B (0.70) | DYRK1ADYRK1BRAB9APIK3CABRAF | |
| SCHEMBL29930851 | 0.74 | DYRK1B (0.73) | DYRK1ADYRK1BMAPTMAPK1 | |
| SCHEMBL28562998 | 0.73 | DYRK1B (0.61) | DYRK1ADYRK1BRAB9AMAPTKDM4E | |
| SCHEMBL29930500 | 0.73 | DYRK1A (0.47) | DYRK1ADYRK1BRAB9AMAPTKDM4E | |
| SCHEMBL29930889 | 0.71 | DYRK1B (0.69) | DYRK1ADYRK1BMAPTBRAFMAPK1 | |
| SCHEMBL29930898 | 0.69 | DYRK1A (0.65) | DYRK1ADYRK1B | |
| SCHEMBL29930763 | 0.68 | DYRK1B (0.71) | DYRK1ADYRK1BRAB9AMAPTBRAF | |
| SCHEMBL1592841 | 0.68 | MAP2K4 (0.45) | DYRK1ARAB9ACLK1KDM4EMAPK1 | |
| SCHEMBL8742187 | 0.68 | KMT2A (0.48) | DYRK1ADYRK1BMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |