Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930702 | 0.90 | DYRK1B (0.73) | DYRK1BDYRK1ABTKTP53MAPT | |
| SCHEMBL29930763 | 0.89 | DYRK1B (0.71) | DYRK1BDYRK1ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29930701 | 0.88 | DYRK1B (0.67) | DYRK1BDYRK1AMAPK1ADORA2ABRAF | |
| SCHEMBL29930851 | 0.81 | DYRK1B (0.73) | DYRK1BDYRK1AMAPK1LMNATP53 | |
| SCHEMBL29930966 | 0.80 | KIT (0.50) | DYRK1BDYRK1AHSD17B10BTKADORA2A | |
| SCHEMBL29930535 | 0.80 | GAA (0.49) | DYRK1BDYRK1AADORA2AADORA1CLK4 | |
| SCHEMBL29930670 | 0.78 | DYRK1B (0.70) | DYRK1BDYRK1ABRAFABCG2KDR | |
| SCHEMBL917608 | 0.72 | MTNR1B (0.65) | MAPK1MEN1KMT2ALMNATSHR | |
| SCHEMBL30080139 | 0.72 | MTNR1B (0.65) | MAPK1MEN1KMT2ALMNATSHR | |
| SCHEMBL674901 | 0.72 | DYRK1B (0.54) | DYRK1BDYRK1ACYP1A2MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |