Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.70 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930763 | 0.90 | DYRK1B (0.71) | DYRK1BDYRK1AGSK3BBRAFRAF1 | |
| SCHEMBL29930701 | 0.87 | DYRK1B (0.67) | DYRK1BDYRK1AGSK3BBRAFNPC1 | |
| SCHEMBL29930851 | 0.84 | DYRK1B (0.73) | DYRK1BDYRK1ASTK10SLKABCG2 | |
| SCHEMBL29930889 | 0.78 | DYRK1B (0.69) | DYRK1BDYRK1ABRAFABCG2KDR | |
| SCHEMBL29930804 | 0.78 | DYRK1A (0.70) | DYRK1BDYRK1ABRAFRAB9APIK3CA | |
| SCHEMBL29930702 | 0.76 | DYRK1B (0.73) | DYRK1BDYRK1ASTK10SLKABCG2 | |
| SCHEMBL1735275 | 0.73 | RAF1 (0.59) | DYRK1BDYRK1AGSK3BBRAFRAF1 | |
| SCHEMBL3225688 | 0.73 | CYP3A4 (0.63) | DYRK1BDYRK1AGSK3BBRAFRAF1 | |
| SCHEMBL29930500 | 0.73 | DYRK1A (0.47) | DYRK1BDYRK1AGSK3BNPC1RAB9A | |
| SCHEMBL28562998 | 0.73 | DYRK1B (0.61) | DYRK1BDYRK1AGSK3BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |