Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611725 | 1.00 | NPC1 (0.60) | NPC1RAB9AKDM4ESGMS2HPGD | |
| SCHEMBL1305662 | 0.93 | HPGD (0.57) | NPC1RAB9AKDM4ESGMS2HPGD | |
| SCHEMBL6771236 | 0.89 | NPC1 (0.60) | NPC1RAB9AKDM4EHPGDLMNA | |
| SCHEMBL23536856 | 0.88 | PTGER1 (0.60) | NPC1RAB9ASGMS2PTGER1MRGPRX4 | |
| SCHEMBL978857 | 0.86 | HTT (0.64) | NPC1SGMS2LMNAPTGER1ALDH1A1 | |
| SCHEMBL3511761 | 0.86 | LMNA (0.63) | NPC1RAB9AKDM4ESGMS2HPGD | |
| SCHEMBL23611722 | 0.86 | NPC1 (0.68) | NPC1RAB9AKDM4ESGMS2LMNA | |
| SCHEMBL29930700 | 0.86 | NPC1 (0.68) | NPC1RAB9AKDM4ESGMS2LMNA | |
| SCHEMBL28862953 | 0.84 | NPC1 (0.56) | NPC1RAB9ASGMS2HPGDPTGER1 | |
| SCHEMBL5940976 | 0.84 | SGMS2 (0.54) | NPC1RAB9AKDM4ESGMS2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |