Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801397 | 0.85 | ACHE (0.39) | ACHEALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL1802615 | 0.84 | ALDH1A1 (0.41) | ACHEALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL1802738 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1800359 | 0.82 | SIGMAR1 (0.41) | ACHEALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL3003170 | 0.80 | — | — | |
| SCHEMBL1800360 | 0.80 | ALDH1A1 (0.38) | ACHEALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL1801453 | 0.80 | MEN1 (0.37) | ACHEALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL1802774 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1798457 | 0.80 | ALDH1A1 (0.41) | ACHEALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL1798991 | 0.79 | ALDH1A1 (0.41) | ACHEALDH1A1KDM4ELMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |