Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931746 | 0.90 | ALDH1A1 (0.40) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29932151 | 0.86 | KMT2A (0.44) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29932027 | 0.84 | ALDH1A1 (0.41) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29932108 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29931920 | 0.80 | GAA (0.37) | ALDH1A1MAPTKMT2ALMNAHTT | |
| SCHEMBL24629102 | 0.80 | MCOLN2 (0.46) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29772915 | 0.80 | MCOLN2 (0.46) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29932109 | 0.80 | MAPT (0.37) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29931852 | 0.79 | KMT2A (0.49) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL29931713 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |