Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932004 | 0.86 | ALDH1A1 (0.40) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29931746 | 0.84 | ALDH1A1 (0.40) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29931830 | 0.83 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29931713 | 0.83 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29932109 | 0.83 | MAPT (0.37) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL21244042 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29932027 | 0.78 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL29932108 | 0.76 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL24629102 | 0.73 | MCOLN2 (0.46) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL23536606 | 0.73 | POLB (0.45) | ALDH1A1MAPTLMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |