Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542866 | 1.00 | OPRL1 (0.47) | OPRL1HTR2AHTR2CHTR2BATM | |
| SCHEMBL22816456 | 0.84 | OPRL1 (0.45) | OPRL1HTR2AHTR2CHTR2BTRPV3 | |
| SCHEMBL17543565 | 0.83 | OPRL1 (0.45) | OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL17543564 | 0.83 | OPRL1 (0.45) | OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL24753039 | 0.82 | MAOA (0.35) | OPRL1TRPV3NPC1RAB9AMAPT | |
| SCHEMBL30120243 | 0.82 | MAOA (0.35) | OPRL1TRPV3NPC1RAB9AMAPT | |
| SCHEMBL433273 | 0.80 | OPRL1 (0.59) | OPRL1HTR2AHTR2CHTR2BMAP3K14 | |
| SCHEMBL20011091 | 0.80 | TRPV3 (0.39) | OPRL1TRPV3NPC1RAB9AALDH1A1 | |
| SCHEMBL1528692 | 0.79 | TRPV3 (0.35) | OPRL1TRPV3NPC1RAB9AALDH1A1 | |
| SCHEMBL20011431 | 0.79 | NPC1 (0.48) | OPRL1HTR2AHTR2CHTR2BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |