Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 3/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931901 | 0.92 | MCOLN2 (0.47) | MCOLN2KMT2AKMOGHSRLIMK2 | |
| SCHEMBL29931911 | 0.90 | MCOLN2 (0.45) | MCOLN2KMT2AKMOGHSRLIMK2 | |
| SCHEMBL23536479 | 0.85 | MCOLN2 (0.48) | MCOLN2KMT2AKMOGHSRLIMK2 | |
| SCHEMBL29948588 | 0.78 | TDP1 (0.32) | — | |
| SCHEMBL29932019 | 0.77 | MCOLN2 (0.49) | MCOLN2KMT2AKMOGHSRLIMK2 | |
| SCHEMBL23057224 | 0.77 | MCOLN2 (0.76) | MCOLN2KMORXFP1KDM4EALDH1A1 | |
| SCHEMBL29932105 | 0.77 | MCOLN2 (0.55) | MCOLN2KMOGHSRLIMK2RXFP1 | |
| SCHEMBL23536230 | 0.77 | MCOLN2 (0.39) | MCOLN2KMT2AKMOGHSRLIMK2 | |
| SCHEMBL23536276 | 0.76 | MCOLN2 (0.48) | MCOLN2KMT2AKMOLIMK2RXFP1 | |
| SCHEMBL29948535 | 0.76 | MCOLN2 (0.48) | MCOLN2KMT2AKMOLIMK2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |