Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 3/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536479 | 0.92 | MCOLN2 (0.48) | MCOLN2RXFP1KMT2AKMOGHSR | |
| SCHEMBL23555092 | 0.89 | MCOLN2 (0.36) | MCOLN2RXFP1KMT2AKMOGHSR | |
| SCHEMBL29932095 | 0.89 | LMNA (0.40) | MCOLN2RXFP1KMT2AGHSRPKM | |
| SCHEMBL23536204 | 0.88 | ALDH1A1 (0.41) | MCOLN2RXFP1KMT2AMEN1L3MBTL1 | |
| SCHEMBL29932183 | 0.88 | ALDH1A1 (0.41) | MCOLN2RXFP1KMT2AMEN1L3MBTL1 | |
| SCHEMBL23555120 | 0.88 | MCOLN2 (0.37) | MCOLN2RXFP1KMT2AKMOGHSR | |
| SCHEMBL28867429 | 0.87 | MCOLN2 (0.34) | MCOLN2RXFP1KMT2AKMOGHSR | |
| SCHEMBL23536196 | 0.84 | MCOLN2 (0.35) | MCOLN2KMT2AKMO | |
| SCHEMBL23536384 | 0.84 | CRHBP (0.34) | MCOLN2KMT2AKMOGHSRCXCR2 | |
| SCHEMBL29931978 | 0.84 | CRHBP (0.34) | MCOLN2KMT2AKMOGHSRCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |