Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029524 | 1.00 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL29115849 | 0.77 | PARP10 (0.52) | PIK3CAPIK3CDCYP1A2PDGFRBPDGFRA | |
| SCHEMBL30718223 | 0.77 | PARP10 (0.52) | PIK3CAPIK3CDCYP1A2PDGFRBPDGFRA | |
| SCHEMBL604021 | 0.76 | ADORA2A (0.46) | PIK3CAMTORCYP1A2SRCALDH1A1 | |
| SCHEMBL32667946 | 0.73 | PDGFRB (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2772360 | 0.73 | PDGFRB (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16200195 | 0.72 | PDGFRB (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6033768 | 0.72 | ALDH1A1 (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL13197745 | 0.72 | PDGFRB (0.59) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17067682 | 0.72 | PDGFRB (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157284-A | CTLA-4 small molecule degradation agent and application thereof | 苏州国匡医药科技有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2022194248-A1 | CTLA-4 SMALL MOLECULE DEGRADATION AGENT AND APPLICATION THEREOF | 苏州国匡医药科技有限公司 | 2022-09-22 | — | — | WO | disclosed |