Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 5/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23364821 | 1.00 | MPL (0.55) | MPLDPP4RORBCDC7CCNE1 | |
| SCHEMBL23364617 | 0.78 | MPL (0.52) | MPLRORBMEN1NPC1RAB9A | |
| SCHEMBL29932908 | 0.78 | MPL (0.52) | MPLRORBMEN1NPC1RAB9A | |
| SCHEMBL23911667 | 0.78 | MPL (0.51) | MPLDPP4RORBCDC7CCNE1 | |
| SCHEMBL2488956 | 0.77 | CDC7 (0.64) | MPLRORBCDC7CCNE1CDK2 | |
| SCHEMBL29932787 | 0.77 | MPL (0.50) | MPLRORBMEN1NPC1RAB9A | |
| SCHEMBL23364828 | 0.77 | MPL (0.50) | MPLRORBMEN1NPC1RAB9A | |
| SCHEMBL31627031 | 0.76 | MYC (0.56) | MEN1KMT2ANPY5RCHEK1DAPK3 | |
| SCHEMBL14660218 | 0.72 | ADORA2A (0.48) | MPLDPP4CDC7CCNE1CDK2 | |
| SCHEMBL6344165 | 0.72 | PIK3R1 (0.50) | MPLDPP4MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058439-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | Genzyme Corporation (US) | 2022-09-21 | — | — | EP | disclosed |
| CN-115003659-A | 5-membered heteroaryl amino sulfonamides for the treatment of conditions mediated by a deficiency in CFTR activity | 健赞公司 | 2022-09-02 | — | — | CN | disclosed |