Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23412056 | 1.00 | CYP11B2 (0.48) | CYP11B2HDAC2HDAC1PDK2MMP2 | |
| SCHEMBL20159003 | 0.85 | MAPT (0.59) | PDK2MMP2MMP13MMP14ADAMTS5 | |
| SCHEMBL31498699 | 0.84 | CYP11B2 (0.50) | CYP11B2HDAC2HDAC1PDK2MMP2 | |
| SCHEMBL31683385 | 0.84 | CYP11B2 (0.51) | CYP11B2CYP3A4HSD17B10ALDH1A1HIF1A | |
| SCHEMBL29933261 | 0.84 | GPR119 (0.62) | CYP11B2CYP3A4HSD17B10ALDH1A1HIF1A | |
| SCHEMBL31091690 | 0.84 | HDAC2 (0.52) | CYP11B2HDAC2HDAC1PDK2CYP3A4 | |
| SCHEMBL1778970 | 0.84 | PDK2 (0.47) | PDK2PARP1TNKSTNKS2CYP3A4 | |
| SCHEMBL30831047 | 0.84 | GPR119 (0.50) | CYP11B2HDAC2HDAC1PDK2PARP1 | |
| SCHEMBL23412152 | 0.83 | CYP3A4 (0.64) | CYP11B2CYP3A4HSD17B10ALDH1A1HIF1A | |
| SCHEMBL23411518 | 0.82 | CYP3A4 (0.55) | CYP11B2CYP3A4HSD17B10ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115210238-B | Substituted aminoquinolones as dgkα inhibitors for immune activation | 拜耳公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-115210238-A | Substituted aminoquinolones as DGK alpha inhibitors for immune activation | 拜耳公司 | 2022-10-18 | — | — | CN | disclosed |