Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.55 |
| ▸ | USP2 | O75604 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485392 | 0.93 | CYP11B2 (0.54) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL29933261 | 0.88 | GPR119 (0.62) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL31683385 | 0.88 | CYP11B2 (0.51) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL23411493 | 0.87 | CYP3A4 (0.53) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL29933185 | 0.87 | CYP3A4 (0.53) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL23440345 | 0.87 | CTSB (0.51) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL23412152 | 0.86 | CYP3A4 (0.64) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL31683443 | 0.85 | CYP11B2 (0.48) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL485072 | 0.84 | CYP3A4 (0.67) | CYP3A4ALDH1A1CYP2C9MAPK1CYP2C19 | |
| SCHEMBL2694775 | 0.83 | SMN1; SMN2 (0.47) | CYP3A4USP2ALDH1A1CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115210238-B | Substituted aminoquinolones as dgkα inhibitors for immune activation | 拜耳公司 | 2024-08-27 | — | — | CN | disclosed |
| US-20230064809-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-03-02 | — | — | US | disclosed |
| CN-115210238-A | Substituted aminoquinolones as DGK alpha inhibitors for immune activation | 拜耳公司 | 2022-10-18 | — | — | CN | disclosed |
| EP-4065584-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2022-10-05 | — | — | EP | disclosed |
| WO-2021105116-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021105116-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230064809-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | DGKK, DGKG, DGKA | CYP3A4 3233/4885USP2 3210/4885ALDH1A1 4261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.