Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 2/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.61 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.61 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.61 |
| ▸ | FEN1 | P39748 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29897963 | 1.00 | ADORA3 (1.00) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL6299915 | 0.81 | ALDH1A1 (0.70) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL31709875 | 0.78 | ADORA3 (0.64) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL9919008 | 0.78 | ADORA3 (0.64) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL8692730 | 0.77 | CYP1A2 (0.76) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL19577287 | 0.76 | ALDH1A1 (0.61) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL29933774 | 0.76 | FEN1 (1.00) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL1520708 | 0.76 | FEN1 (1.00) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL3754362 | 0.76 | ALDH1A1 (1.00) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL13947065 | 0.76 | ALDH1A1 (0.61) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916573-B2 | Quinazoline-2,4-dione derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-12-23 | — | — | US | claimed |
| US-20140171425-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-06-19 | — | — | US | claimed |
| EP-2742042-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2014-06-18 | — | — | EP | claimed |
| WO-2013021363-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-02-14 | — | — | WO | claimed |
| EP-0276436-A1 | Phosphinic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-08-03 | — | — | EP | claimed |
| US-20230159608-A1 | MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND USES THEREOF | LUNG THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2022133551-A1 | HISTONE DEACETYLASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2022-06-30 | — | — | WO | disclosed |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
| EP-3957633-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |
| WO-2019101551-A1 | HERBICIDAL PHENYLETHERS | BASF SE (DE) | 2019-05-31 | — | — | WO | disclosed |
| WO-2019101513-A1 | HERBICIDAL PYRIDYLETHERS | BASF SE (DE) | 2019-05-31 | — | — | WO | disclosed |
| US-4780539-A | ANTICONVULSANTS, ANXIOLYTIC AGENTS | A/S FERROSAN (DK) | 1988-10-25 | — | — | US | disclosed |
| EP-0283162-A2 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-21 | — | — | EP | disclosed |
| US-4771051-A | CENTRAL NERVOUS SYSTEM DISORDERS | A/S FERROSAN (DK) | 1988-09-13 | — | — | US | disclosed |
| EP-0276436-A1 | Phosphinic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-08-03 | — | — | EP | disclosed |
| EP-0274009-A1 | Oxadiazolylacetonitriles, their preparation and use | NOVO NORDISK A/S (DK) | 1988-07-13 | — | — | EP | disclosed |
| EP-0226282-A2 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-06-24 | — | — | EP | disclosed |
| US-4551458-A | 1-HALOALKYLTHIO DERIVATIVES | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 1985-11-05 | — | — | US | disclosed |
| US-3947416-A | Azaisatoic anhydrides | THE SHERWIN-WILLIAMS COMPANY (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ADORA3 1388/4885ADORA2B 616/4885ADORA2A 2215/4885 |
| US-20140171425-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES | NQO2, H1-3, H1-0 | ADORA3 1306/4885ADORA2B 3404/4885ADORA2A 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.