Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 9/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29934245 | 0.83 | HDAC1 (0.43) | KDRKCNH2CYP11B2HDAC1 | |
| SCHEMBL29934041 | 0.81 | KCNH2 (0.43) | KDRFGFR3KCNH2CYP11B2HDAC1 | |
| SCHEMBL23501690 | 0.81 | BACE1 (0.46) | KCNH2CYP11B2BACE1 | |
| SCHEMBL29933841 | 0.81 | BACE1 (0.46) | KCNH2CYP11B2BACE1 | |
| SCHEMBL29935119 | 0.79 | SMN1; SMN2 (0.41) | KDRFGFR3CYP11B2SIRT2SIRT3 | |
| SCHEMBL29933857 | 0.76 | MAPT (0.49) | — | |
| SCHEMBL23501696 | 0.76 | MAPT (0.49) | — | |
| SCHEMBL29934919 | 0.73 | CYP11B2 (0.39) | KCNH2CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL31359374 | 0.72 | MKNK1 (0.38) | KCNH2CYP11B2 | |
| SCHEMBL29933066 | 0.72 | CNR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115315421-A | Compounds and compositions as PDGF receptor kinase inhibitors | 日本新药株式会社 | 2022-11-08 | — | — | CN | disclosed |