Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31359374 | 0.87 | MKNK1 (0.38) | KCNH2AURKAAURKBKDM4CCYP11B2 | |
| SCHEMBL28884710 | 0.84 | KDM4C (0.43) | KCNH2KDM4CKCNA5CYP11B2ABL1 | |
| SCHEMBL29934030 | 0.84 | KDM4C (0.43) | KCNH2KDM4CKCNA5CYP11B2ABL1 | |
| SCHEMBL29934245 | 0.82 | HDAC1 (0.43) | KCNH2KDRAURKAAURKBMEN1 | |
| SCHEMBL28884685 | 0.82 | ABL1 (0.44) | RAB9AKDM4CCYP11B2ABL1SRC | |
| SCHEMBL29934296 | 0.81 | KDR (0.48) | KCNH2KDRFGFR3CYP11B2HDAC1 | |
| SCHEMBL31359380 | 0.75 | MKNK1 (0.53) | KDM4CCYP11B2HDAC3HDAC1HDAC8 | |
| SCHEMBL29934825 | 0.75 | CYP11B2 (0.33) | KCNH2KMT2AMAPTKCNA5CYP11B2 | |
| SCHEMBL29932952 | 0.73 | CNR1 (0.42) | — | |
| SCHEMBL29932961 | 0.73 | CNR1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115315421-A | Compounds and compositions as PDGF receptor kinase inhibitors | 日本新药株式会社 | 2022-11-08 | — | — | CN | disclosed |