Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | NOS2 | P35228 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | KRAS | P01116 | 6/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22028956 | 1.00 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1NOS3NOS1NOS2 | |
| SCHEMBL22655924 | 0.80 | SMN1; SMN2 (0.46) | HSP90AA1HSP90AB1POLB | |
| SCHEMBL21733973 | 0.80 | NOS2 (0.40) | HSP90AA1HSP90AB1NOS3NOS1NOS2 | |
| SCHEMBL24272756 | 0.80 | ALDH1A1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL24331214 | 0.80 | BACE1 (0.34) | HSP90AA1HSP90AB1NOS3NOS2BACE1 | |
| SCHEMBL24756842 | 0.80 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1NOS3NOS1NOS2 | |
| SCHEMBL30415850 | 0.80 | ALDH1A1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL22028950 | 0.77 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1NOS3NOS1NOS2 | |
| SCHEMBL29851065 | 0.77 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1NOS3NOS1NOS2 | |
| SCHEMBL23174470 | 0.77 | LMNA (0.37) | HSP90AA1HSP90AB1AGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4716531-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | Board of Regents, The University of Texas System (US) | 2026-04-01 | — | — | EP | disclosed |
| EP-4551577-A1 | FUSED RING KRAS INHIBITORS FOR TREATING DISEASE | Blossomhill Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| CN-119790058-A | Fused cyclic KRAS inhibitors for the treatment of diseases | 荣山医药股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-119192133-A | Synthesis of quinazoline compounds | 基因泰克公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119192134-A | Synthesis of quinazoline compounds | 基因泰克公司 | 2024-12-27 | — | — | CN | disclosed |
| WO-2024243186-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-11-28 | — | — | WO | disclosed |
| CN-116057052-B | Synthesis of quinazoline compounds | 基因泰克公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-118084867-A | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084870-A | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084866-A | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084868-A | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112105419-B | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2024015262-A1 | FUSED RING KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2023173014-A1 | KRAS INHIBITORS AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-09-14 | — | — | WO | disclosed |
| CN-116057052-A | Synthesis of quinazoline compounds | 基因泰克公司 | 2023-05-02 | — | — | CN | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |