Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 8/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 8/20 | 0.41 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NAAA | Q02083 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16111541 | 0.80 | LMNA (0.50) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL29543136 | 0.78 | POLB (0.51) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL3587332 | 0.78 | POLB (0.51) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL1978881 | 0.78 | CHRNB2 (0.56) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL2300122 | 0.76 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL20912047 | 0.76 | POLB (0.56) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL23231374 | 0.76 | NR1H2 (0.48) | SMN1; SMN2CHRNB2CHRNA4CHRNA3CHRNB3 | |
| SCHEMBL29344011 | 0.76 | NR1H2 (0.48) | SMN1; SMN2CHRNB2CHRNA4CHRNA3CHRNB3 | |
| SCHEMBL19308675 | 0.75 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL1633241 | 0.73 | LMNA (0.56) | LMNAPOLBSMN1; SMN2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |