Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | MPI | P34949 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558147 | 1.00 | KDM4E (0.61) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL2170981 | 0.84 | KMT2A (0.59) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL196848 | 0.83 | KMT2A (0.68) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL19990071 | 0.83 | KDM4E (0.70) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL18280047 | 0.77 | SLC40A1 (0.48) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL24876033 | 0.76 | KDM4E (0.61) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL3559305 | 0.76 | KDM4E (0.61) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL12566070 | 0.76 | KDM4E (0.55) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL2208961 | 0.76 | KDM4E (0.61) | KDM4EL3MBTL1MPIMAPTMEN1 | |
| SCHEMBL2557719 | 0.76 | L3MBTL1 (0.61) | KDM4EL3MBTL1MPIMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |