Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.40 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398913 | 0.85 | CDK5 (0.40) | RIPK1PRMT5WDR77HHATKMT2A | |
| SCHEMBL38659451 | 0.81 | HSD11B1 (0.51) | RIPK1PRMT5WDR77HSD11B1NPC1 | |
| SCHEMBL8296762 | 0.81 | HSD11B1 (0.51) | RIPK1PRMT5WDR77HSD11B1NPC1 | |
| SCHEMBL29504572 | 0.80 | PRMT5 (0.55) | RIPK1PRMT5WDR77HSD11B1NPC1 | |
| SCHEMBL31430923 | 0.80 | PRMT5 (0.55) | RIPK1PRMT5WDR77HSD11B1NPC1 | |
| SCHEMBL30499343 | 0.77 | RIPK1 (0.42) | RIPK1PRMT5WDR77HHATNPC1 | |
| SCHEMBL29933840 | 0.76 | PIK3C3 (0.41) | RIPK1PRMT5WDR77HHATKMT2A | |
| SCHEMBL5321655 | 0.75 | RIPK1 (0.40) | RIPK1HHAT | |
| SCHEMBL30764694 | 0.74 | MAPT (0.39) | KMT2ANPC1ALDH1A1MEN1DRD4 | |
| SCHEMBL5466839 | 0.74 | HSD11B1 (0.41) | HSD11B1GRM5DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110997681-B | Thiazolopyridine derivatives as adenosine receptor antagonists | 默克专利股份公司 | 2022-11-15 | — | — | CN | disclosed |