Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302752 | 1.00 | KLKB1 (0.33) | KLKB1 | |
| SCHEMBL29277999 | 0.89 | KLKB1 (0.31) | KLKB1 | |
| SCHEMBL17442547 | 0.77 | KLKB1 (0.35) | KLKB1 | |
| SCHEMBL29940462 | 0.76 | KLKB1 (0.34) | KLKB1 | |
| SCHEMBL17442573 | 0.76 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL29302757 | 0.76 | KLKB1 (0.34) | KLKB1 | |
| SCHEMBL21027918 | 0.74 | KLKB1 (0.37) | KLKB1 | |
| SCHEMBL21177281 | 0.73 | SIRT1 (0.38) | KLKB1 | |
| SCHEMBL19780120 | 0.72 | KLKB1 (0.40) | KLKB1 | |
| SCHEMBL19780593 | 0.71 | KLKB1 (0.37) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396469-A | Inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |