Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302757 | 1.00 | KLKB1 (0.34) | KLKB1LOXL2LOXLOXL3MAP4K1 | |
| SCHEMBL17442547 | 0.85 | KLKB1 (0.35) | KLKB1BACE1CYP3A4CYP2D6BACE2 | |
| SCHEMBL17442573 | 0.83 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL21177281 | 0.80 | SIRT1 (0.38) | KLKB1MAP4K1CYP3A4 | |
| SCHEMBL19780120 | 0.80 | KLKB1 (0.40) | KLKB1MAP4K1 | |
| SCHEMBL19780593 | 0.78 | KLKB1 (0.37) | KLKB1 | |
| SCHEMBL19779861 | 0.77 | CYP1A2 (0.38) | KLKB1MAP4K1CYP3A4 | |
| SCHEMBL21179367 | 0.76 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL29940339 | 0.76 | KLKB1 (0.33) | KLKB1 | |
| SCHEMBL29302752 | 0.76 | KLKB1 (0.33) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |