Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252336 | 1.00 | KMT2A (0.60) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL1429298 | 0.89 | AKR1B1 (0.55) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL1867904 | 0.89 | NLRP3 (0.54) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL4331423 | 0.88 | SMN1; SMN2 (0.56) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| Ammonia Solution, Strong SCHEMBL27532390 | 0.87 | AKR1B1 (0.53) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL7638197 | 0.85 | KMT2A (0.56) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL12023029 | 0.84 | NLRP3 (0.50) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL838467 | 0.84 | SMN1; SMN2 (0.74) | KMT2AMEN1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL31514215 | 0.84 | NLRP3 (0.54) | KMT2AMEN1ATMLMNAALDH1A1 | |
| SCHEMBL23425650 | 0.83 | CA12 (0.50) | KMT2AMEN1ATMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051671-A1 | FLUORINATED QUINOLINE, QUINOXALINE AND BENZO[B][1,4]OXAZINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES | Janssen Biotech, Inc. (US) | 2022-09-07 | — | — | EP | disclosed |