Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11305630 | 0.90 | NLRP3 (0.52) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL29943508 | 0.88 | KMT2A (0.60) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL5252336 | 0.88 | KMT2A (0.60) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL4468837 | 0.86 | KMT2A (0.53) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL12049934 | 0.81 | KMT2A (0.55) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL7638197 | 0.80 | KMT2A (0.56) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL838467 | 0.79 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL5254398 | 0.79 | KDM4E (0.56) | SMN1; SMN2ALDH1A1KMT2AMAPTGAA | |
| SCHEMBL3021788 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL3021784 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146696-A1 | USE OF INDOLE-3-CARBOXYLIC ESTERS FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE | Universität Tübingen (DE) | 2009-12-10 | — | — | WO | disclosed |