Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.55 |
| ▸ | NPC1 | O15118 | 12/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | GAA | P10253 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | GLA | P06280 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000545 | 0.84 | SMN1; SMN2 (0.50) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3002189 | 0.79 | ALOX5AP (0.43) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3091208 | 0.78 | TP53 (0.42) | KDM4EALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL2996124 | 0.77 | KMT2A (0.47) | RAB9ANPC1KDM4EALDH1A1GAA | |
| SCHEMBL2992051 | 0.77 | PDE10A (0.38) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2997210 | 0.77 | HPGD (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL3002623 | 0.77 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL2994531 | 0.76 | ALOX5AP (0.49) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2999919 | 0.76 | CYP1A2 (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL2990181 | 0.76 | MAPK14 (0.54) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | RAB9A 4316/4885NPC1 603/4885KDM4E 2671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.