Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630351 | 1.00 | PIK3CA (0.41) | PIK3CAIDEOPRD1KCNH2SMO | |
| SCHEMBL23630383 | 0.77 | PIK3CA (0.48) | PIK3CAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29944012 | 0.77 | PIK3CA (0.47) | PIK3CAMEN1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL23630466 | 0.77 | PIK3CA (0.47) | PIK3CAMEN1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL29943886 | 0.76 | PIK3CA (0.54) | PIK3CAALDH1A1GAA | |
| SCHEMBL23630405 | 0.76 | PIK3CA (0.54) | PIK3CAALDH1A1GAA | |
| SCHEMBL29944433 | 0.76 | CKS1B (0.47) | PIK3CAIDEOPRD1KCNH2SMO | |
| SCHEMBL23630396 | 0.76 | CKS1B (0.47) | PIK3CAIDEOPRD1KCNH2SMO | |
| SCHEMBL23630379 | 0.76 | GABRP (0.45) | PIK3CAOPRD1PANK3GRM5 | |
| SCHEMBL29944108 | 0.76 | GABRP (0.45) | PIK3CAOPRD1PANK3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |