Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630466 | 1.00 | PIK3CA (0.47) | PIK3CAHRH3NPC1KDM4ERAB9A | |
| SCHEMBL29943886 | 0.86 | PIK3CA (0.54) | PIK3CAKDM4EKDM5AKDM5BKDM4C | |
| SCHEMBL23630405 | 0.86 | PIK3CA (0.54) | PIK3CAKDM4EKDM5AKDM5BKDM4C | |
| SCHEMBL29943975 | 0.81 | NPC1 (0.54) | NPC1KDM4ERAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL23630487 | 0.81 | NPC1 (0.54) | NPC1KDM4ERAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL23630325 | 0.81 | AOC3 (0.40) | PIK3CAHRH3SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29943895 | 0.81 | AOC3 (0.40) | PIK3CAHRH3SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23630351 | 0.77 | PIK3CA (0.41) | PIK3CANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL29944125 | 0.77 | PIK3CA (0.41) | PIK3CANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL23630379 | 0.77 | GABRP (0.45) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |