Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.41 |
| ▸ | KDM5A | P29375 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630405 | 1.00 | PIK3CA (0.54) | PIK3CAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23630466 | 0.86 | PIK3CA (0.47) | PIK3CAKDM4CKDM5BKDM5AKDM4E | |
| SCHEMBL29944012 | 0.86 | PIK3CA (0.47) | PIK3CAKDM4CKDM5BKDM5AKDM4E | |
| SCHEMBL23630324 | 0.83 | SMO (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29944108 | 0.83 | GABRP (0.45) | PIK3CAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23630379 | 0.83 | GABRP (0.45) | PIK3CAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29943898 | 0.81 | AOC3 (0.40) | PIK3CAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL23630479 | 0.81 | AOC3 (0.40) | PIK3CAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL23630485 | 0.80 | ALDH1A1 (0.55) | KDM4EGAAHSD17B10L3MBTL1ALDH1A1 | |
| SCHEMBL29944092 | 0.80 | ALDH1A1 (0.55) | KDM4EGAAHSD17B10L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |