Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 6/20 | 0.63 |
| ▸ | SREBF1 | P36956 | 6/20 | 0.63 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | EDNRA | P25101 | 4/20 | 0.53 |
| ▸ | EDNRB | P24530 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27245384 | 1.00 | NR1H3 (0.63) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL27245351 | 0.92 | NR1H3 (0.64) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL29944893 | 0.92 | NR1H3 (0.64) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL27030595 | 0.88 | EDNRA (0.61) | SREBF1MAPK1EDNRAEDNRBSMN1; SMN2 | |
| SCHEMBL27030601 | 0.79 | SREBF1 (0.89) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL30300538 | 0.79 | MAPK1 (0.69) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL27245361 | 0.78 | SREBF1 (0.89) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL29944859 | 0.78 | SREBF1 (0.89) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL29944870 | 0.78 | MEN1 (0.58) | NR1H3SREBF1NR1H2MAPK1HSD17B10 | |
| SCHEMBL27245391 | 0.78 | MEN1 (0.58) | NR1H3SREBF1NR1H2MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308554-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | The Board of Trustees of the University of Illinois (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197658-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-09-22 | — | — | WO | disclosed |