Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 4/20 | 0.64 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.64 |
| ▸ | SREBF1 | P36956 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | EDNRA | P25101 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944893 | 1.00 | NR1H3 (0.64) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL27245384 | 0.92 | NR1H3 (0.63) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL29944956 | 0.92 | NR1H3 (0.63) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL27030597 | 0.85 | EDNRA (0.66) | EDNRATSHR | |
| SCHEMBL7533552 | 0.84 | NR1H3 (0.57) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL30300538 | 0.82 | MAPK1 (0.69) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL27030595 | 0.81 | EDNRA (0.61) | SREBF1MAPK1EDNRARAB9ASMN1; SMN2 | |
| SCHEMBL29944871 | 0.79 | SREBF1 (0.79) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL27245334 | 0.79 | SREBF1 (0.79) | NR1H3NR1H2SREBF1HSD17B10MAPK1 | |
| SCHEMBL27030601 | 0.79 | SREBF1 (0.89) | NR1H3NR1H2SREBF1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199572-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240199572-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING TYPE 2 DIABETES AND DEMENTIA | SREBF2, SREBF1, SLC2A2 | NR1H3 21/4885NR1H2 14/4885SREBF1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.