Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23526090 | 1.00 | PDE5A (0.38) | PDE5APDE3BPDE3AKDM4EENPP1 | |
| SCHEMBL8857450 | 0.83 | ENPP1 (0.44) | PDE5APDE3BPDE3AKDM4EENPP1 | |
| SCHEMBL29945847 | 0.83 | ENPP1 (0.44) | PDE5APDE3BPDE3AKDM4EENPP1 | |
| SCHEMBL25839210 | 0.80 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL29945802 | 0.79 | PDE3B (0.38) | PDE5APDE3BPDE3AKDM4EAURKA | |
| SCHEMBL4115923 | 0.79 | DYRK1A (0.44) | PDE5AKDM4EENPP1PDE10AMAPT | |
| SCHEMBL29945735 | 0.74 | KDM4E (0.42) | PDE5APDE3BPDE3AKDM4EENPP1 | |
| SCHEMBL23526128 | 0.74 | KDM4E (0.42) | PDE5APDE3BPDE3AKDM4EENPP1 | |
| SCHEMBL30014008 | 0.71 | ALDH1A1 (0.50) | PDE3BPDE3AKDM4ESOS1PDE10A | |
| SCHEMBL29230204 | 0.70 | SMN1; SMN2 (0.50) | PDE3BPDE3AKDM4EALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462626-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-115135315-B | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |