Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 14/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 13/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.68 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993358 | 0.90 | ADRB2 (0.65) | ADRB2ADRB3ADRB1DNM1DRD2 | |
| SCHEMBL2999951 | 0.87 | ADRB2 (0.75) | ADRB2ADRB3ADRB1DNM1TLR4 | |
| SCHEMBL2998028 | 0.83 | ADRB2 (0.61) | ADRB2ADRB3ADRB1DNM1ABCB1 | |
| SCHEMBL2997640 | 0.83 | ADRB3 (0.61) | ADRB2ADRB3ADRB1DNM1 | |
| SCHEMBL4606756 | 0.83 | ADRB3 (0.47) | ADRB2ADRB3ADRB1DNM1MAPK1 | |
| SCHEMBL16550136 | 0.82 | MAPT (0.71) | ADRB2ADRB3ADRB1DRD2KDM4E | |
| SCHEMBL2992569 | 0.82 | ADRB3 (0.72) | ADRB2ADRB3ADRB1DNM1TLR4 | |
| SCHEMBL3000457 | 0.81 | ADRB1 (0.71) | ADRB2ADRB3ADRB1DNM1ABCB1 | |
| SCHEMBL2997254 | 0.81 | MEN1 (0.64) | ADRB2ADRB3ADRB1KDM4EGAA | |
| SCHEMBL1351463 | 0.80 | ADRB3 (0.73) | ADRB2ADRB3ADRB1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786142-B2 | Heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2010-08-31 | — | — | US | claimed |
| US-20070111998-A1 | Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2007-05-17 | — | — | US | claimed |
| US-7786142-B2 | Heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2010-08-31 | — | — | US | disclosed |
| US-7786142-B2 | Heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2010-08-31 | — | — | US | disclosed |
| US-7786142-B2 | Heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2010-08-31 | — | — | US | disclosed |
| US-20070111998-A1 | Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2007-05-17 | — | — | US | disclosed |
| US-20070111998-A1 | Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2007-05-17 | — | — | US | disclosed |
| US-20070111998-A1 | Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors | ORCHID RESEARCH LABORATORIES, LTD. (IN) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111998-A1 | Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors | IL6, IL6ST, STAT3 | ADRB2 4160/4885ADRB3 3238/4885ADRB1 3273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.