SCHEMBL29946112

SCHEMBL29946112

COC(=O)Cc1cc(C)c(Br)cc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.43
FGFR1 P11362 1/20 0.43
PDGFRA P16234 1/20 0.43
FLT1 P17948 1/20 0.43
FGFR3 P22607 1/20 0.43
KDR P35968 1/20 0.43
HSP90AB1 P08238 1/20 0.39
RORC P51449 1/20 0.37
ALDH1A1 P00352 4/20 0.37
MTNR1A P48039 2/20 0.37
MTNR1B P49286 2/20 0.37
KDM4E B2RXH2 3/20 0.35
GLA P06280 2/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
KMT2A Q03164 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22830400 1.00 PDGFRB (0.43) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL29737923 0.87 RORC (0.41) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL22527805 0.87 RORC (0.41) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL27176850 0.85 EGFR (0.43) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL7098144 0.85 PDGFRB (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL31463372 0.84 CCR6 (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL15912510 0.83 MTNR1A (0.48) RORCALDH1A1MTNR1AMTNR1B
SCHEMBL31463394 0.83 MTNR1A (0.48) RORCALDH1A1MTNR1AMTNR1B
SCHEMBL27467592 0.82 PDGFRB (0.43) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL30027997 0.81 AGBL2 (0.40) HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114008033-B Glucagon-like peptide 1 receptor agonists 伊莱利利公司 2025-01-10 CN disclosed
CN-114728923-B Processes and intermediates for the preparation of oxetan-2-ylmethylamine 伊莱利利公司 2024-12-24 CN disclosed
WO-2022184849-A1 GLP-1R AGONISTS, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF LES LABORATOIRES SERVIER (FR) 2022-09-09 WO disclosed