Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29126309 | 1.00 | CHRNA7 (0.57) | CHRNA7HTR7GAARAD52ALDH1A1 | |
| SCHEMBL29442412 | 0.82 | ALDH1A1 (0.64) | HTR7GAAALDH1A1KDM4EMAPT | |
| SCHEMBL1444185 | 0.82 | ALDH1A1 (0.64) | HTR7GAAALDH1A1KDM4EMAPT | |
| SCHEMBL5356967 | 0.80 | ALDH1A1 (0.66) | CHRNA7GAARAD52ALDH1A1TDP1 | |
| SCHEMBL1443579 | 0.80 | TRIM24 (0.60) | HTR7GAAALDH1A1KDM4EMAPT | |
| SCHEMBL29377692 | 0.80 | TRIM24 (0.60) | HTR7GAAALDH1A1KDM4EMAPT | |
| SCHEMBL6729461 | 0.79 | AR (0.46) | CHRNA7HTR7GAARAD52DRD2 | |
| SCHEMBL18741400 | 0.79 | CHRNA7 (0.62) | CHRNA7HTR7GAARAD52ALDH1A1 | |
| SCHEMBL10294634 | 0.79 | KCNH2 (0.69) | CHRNA7KCNH2 | |
| SCHEMBL3210432 | 0.79 | HTR7 (0.58) | HTR7DRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981666-A | Fused tetracyclic compound, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2022199676-A1 | FUSED TETRACYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2022-09-29 | — | — | WO | disclosed |