Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536268 | 1.00 | GPR119 (0.50) | GPR119FPR2PROKR1NPBWR1MCHR1 | |
| SCHEMBL2774363 | 0.90 | GPR119 (0.51) | GPR119PIK3CD | |
| SCHEMBL23311666 | 0.83 | GPR119 (0.57) | GPR119NPBWR1MCHR1 | |
| SCHEMBL2636750 | 0.83 | HSD11B1 (0.56) | PIK3CD | |
| SCHEMBL25113635 | 0.83 | GPR119 (0.49) | GPR119NPBWR1MCHR1PIK3CD | |
| SCHEMBL2636748 | 0.83 | HSD11B1 (0.56) | PIK3CD | |
| SCHEMBL12211468 | 0.83 | MEN1 (0.48) | GPR119CYP3A4CYP3A5 | |
| SCHEMBL28671495 | 0.82 | GPR119 (0.56) | GPR119PIK3CD | |
| SCHEMBL20135006 | 0.82 | PIK3CD (0.56) | PIK3CD | |
| SCHEMBL20135004 | 0.82 | PIK3CD (0.56) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337206-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | Libra Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240992-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |