Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.33 |
| ▸ | CBLB | Q13191 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26981246 | 1.00 | KDM4E (0.37) | KDM4ELMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL25272192 | 0.81 | CYP1A2 (0.47) | KDM4EMAPK1KMT2AALDH1A1HPGD | |
| SCHEMBL30595867 | 0.81 | CYP1A2 (0.47) | KDM4EMAPK1KMT2AALDH1A1HPGD | |
| SCHEMBL22481338 | 0.78 | P2RX7 (0.49) | LMNAMAPK1KMT2AALDH1A1HPGD | |
| SCHEMBL172147 | 0.76 | CBLB (0.32) | CBLB | |
| SCHEMBL24724317 | 0.76 | KDM4E (0.35) | KDM4EMAPK1KMT2AALDH1A1HPGD | |
| SCHEMBL30003361 | 0.76 | KDM4E (0.35) | KDM4EMAPK1KMT2AALDH1A1HPGD | |
| SCHEMBL29882431 | 0.76 | HSP90AA1 (0.39) | KDM4ELMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL23580481 | 0.76 | HSP90AA1 (0.39) | KDM4ELMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL17819677 | 0.74 | KDM4E (0.32) | KDM4EALDH1A1HPGDCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301468-A1 | FGFR3 INHIBITOR COMPOUNDS | Eli Lilly and Company (US) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022187443-A1 | FGFR3 INHIBITOR COMPOUNDS | ELI LILLY AND COMPANY (US) | 2022-09-09 | — | — | WO | disclosed |